The EU-funded FISHY project aims to design, develop, validate and demonstrate a coordinated framework for cyber resilience to guarantee a trusted supply chain of ICT systems. The project is implementing new strategies to leverage data analytics, distributed ledger technology, intent-based security service orchestration, artificial intelligence and programmable network infrastructure. The vision for this new platform is that it will not only facilitate adaptive system reconfigurations but also react to and defy the effects of cyber attacks in real time in the ICT supply chain end-to-end, and in particular in the Internet of Things domain